Publications

2024

Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements

Sandra Iñiguez-Muñoz , Pere Llinàs-Arias , Miquel Ensenyat-Mendez , Andrés F Bedoya-López , Javier I J Orozco , Javier Cortés , Ananya Roy , Karin Forsberg-Nilsson, Maggie L DiNome, Diego M Marzese 

Cell Mol Life Sci. 2024 Jun 20;81(1):274. doi: 10.1007/s00018-024-05314-z.

PMID: 38902506.

2023

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

Pere Llinàs‐Arias, Miquel Ensenyat‐Méndez, Sandra Íñiguez‐Muñoz, Javier I. J. Orozco, Betsy Valdez, Matthew P Salomon, Chikako Matsuba, Maria Solivellas-Pieras, Andrés F Bedoya-López, Borja Sesé, Anja Mezger, Mattias Ormestad, Fernando Unzueta, Siri H Strand, Alexander D Boiko, E Shelley Hwang, Javier Cortés, Maggie L DiNome, Manel Esteller, Mathieu Lupien, Diego M Marzese 

BMC Molecular Cancer. 2023. PMID: 38017545 PMCID: PMC10683115 DOI: 10.1186/s12943-023-01906-8


3‐D chromatin conformation, accessibility, and gene expression profiling of triple‐negative breast cancer.

Pere Llinàs‐Arias, Miquel Ensenyat‐Méndez, Javier I. J. Orozco, Sandra Íñiguez‐Muñoz, Betsy Valdez, Chuan Wang, Anja Mezger, Eunkyoung Choi, Yan Zhou Tran, Liqun Yao, Franziska Bonath, Remi‐André Olsen, Mattias Ormestad, Manel Esteller, Mathieu Lupien and Diego M. Marzese

BMC Genomic Data. 2023;24:61.

Epigenetic Profiles of Triple-Negative Breast Cancer of African American and White Females. 

Ensenyat-Mendez M, Solivellas-Pieras M, Llinàs-Arias P, Íñiguez-Muñoz S, Baker JL, Marzese DM, DiNome ML.

JAMA Netw Open. 2023 Oct 2;6(10):e2335821. doi: 10.1001/jamanetworkopen.2023.35821. PMID: 37796506

Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer.

Ensenyat-Mendez M, Orozco JIJ, Llinàs-Arias P, Íñiguez-Muñoz S, Baker JL, Salomon MP, Martí M, DiNome ML, Cortés J, Marzese DM.

Commun Med (Lond). 2023 Jul 10;3(1):93. doi: 10.1038/s43856-023-00311-y. PMID: 37430006


Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma.

Chagani S, De Macedo MP, Carapeto F, Wang F, Marzese DM, Wani K, Haydu LE, Peng W, Ong GT, Warren SE, Beechem JM, Hoon DSB, Mills GB, Tetzlaff MT, Lazar AJ, Kwong LN, Davies MA.

J Invest Dermatol. 2023 Mar 4:S0022-202X(23)00164-1. doi: 10.1016/j.jid.2023.01.034. PMID: 36871660

2022

Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells.

Carrier A, Desjobert C, Lobjois V, Rigal L, Busato F, Tost J, Ensenyat-Mendez M, Marzese DM, Pradines A, Favre G, Lamant L, Lanfrancone L, Etievant C, Arimondo PB, Riond J.

Clin Epigenetics. 2022 Nov 28;14(1):156. doi: 10.1186/s13148-022-01364-x.

PMID: 36443814.


Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer.

Orozco JIJ, Le J, Ensenyat-Mendez M, Baker JL, Weidhaas J, Klomhaus A, Marzese DM, DiNome ML.

Ann Surg Oncol. 2022 Jul 16. doi: 10.1245/s10434-022-12143-6. Online ahead of print.

PMID: 35842534


Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype

Sesé B, Íñiguez-Muñoz S, Ensenyat-Mendez M, Llinàs-Arias P, Ramis G, Orozco JIJ, Fernández de Mattos S, Villalonga P and Marzese DM

Cancers (Basel). 2022 Epub ahead of print


Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease.

Ensenyat-Mendez M, Rünger D, Orozco JIJ, Le J, Baker JL, Weidhaas J, Marzese DM, DiNome ML.

Ann Surg Oncol. 2022 Aug;29(8):4716-4724. doi: 10.1245/s10434-022-11684-0. Epub 2022 Apr 9.

PMID: 35397740


LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer.

Pérez-Núñez I, Rozalén C, Palomeque JÁ, Sangrador I, Dalmau M, Comerma L, Hernández-Prat A, Casadevall D, Menendez S, Liu DD, Shen M, Berenguer J, Ruiz IR, Peña R, Montañés JC, Albà MM, Bonnin S, Ponomarenko J, Gomis RR, Cejalvo JM, Servitja S, Marzese DM, Morey L, Voorwerk L, Arribas J, Bermejo B, Kok M, Pusztai L, Kang Y, Albanell J, Celià-Terrassa T.

Nat Cancer. 2022 Mar;3(3):355-370. doi: 10.1038/s43018-022-00339-4. Epub 2022 Mar 17.

PMID: 35301507

 

When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

Masuelli S, Real S, Campoy E, Branham MT, Marzese DM, Salomon M, De Blas G, Arias R, Levin M, Roqué M.

Mol Med. 2022 Feb 5;28(1):15. doi: 10.1186/s10020-022-00440-5.

PMID: 35123413


Establishing Novel Molecular Subtypes of Appendiceal Cancer

Garland-Kledzik M, Scholer A, Ensenyat-Mendez M, Orozco JIJ, Khader A, Santamaria-Barria J, Fischer T, Pigazzi A, Marzese DM.

Ann Surg Oncol. 2022 Mar;29(3):2118-2125. doi: 10.1245/s10434-021-10945-8. Epub 2021 Oct 30.

PMID: 34718915

2021

Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer.

Llinàs-Arias P, Íñiguez-Muñoz S, McCann K, Voorwerk L, Orozco JIJ, Ensenyat-Mendez M, Sesé B, DiNome ML, Marzese DM.

Cancers (Basel). 2021 Aug 17;13(16):4139. doi: 10.3390/cancers13164139.

PMID: 34439290


iGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes.

Ensenyat-Mendez M, Íñiguez-Muñoz S, Sesé B, Marzese DM.

BioData Min. 2021 Aug 23;14(1):42. doi: 10.1186/s13040-021-00273-8.

PMID: 34425860


Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology.

Sesé B, Ensenyat-Mendez M, Iñiguez S, Llinàs-Arias P, Marzese DM.

Clin Epigenetics. 2021 Jul 31;13(1):150. doi: 10.1186/s13148-021-01139-w.

PMID: 34332627 


Is the 21-Gene Recurrence Score on Core Needle Biopsy Equivalent to Surgical Specimen in Early-Stage Breast Cancer? A Comparison of Gene Expression Between Paired Core Needle Biopsy and Surgical Specimens.

Orozco JIJ, Chang SC, Matsuba C, Ensenyat-Mendez M, Grunkemeier GL, Marzese DM, Grumley JG.

Ann Surg Oncol. 2021 Jul 9. doi: 10.1245/s10434-021-10457-5. Online ahead of print.

PMID: 34244898


Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer.

Ensenyat-Mendez M, Llinàs-Arias P, Orozco JIJ, Íñiguez-Muñoz S, Salomon MP, Sesé B, DiNome ML, Marzese DM.

Front Oncol. 2021 Jun 16;11:681476. doi: 10.3389/fonc.2021.681476. eCollection 2021.

PMID: 34221999


A Systems Approach to Brain Tumor Treatment.

Park JH, de Lomana ALG, Marzese DM, Juarez T, Feroze A, Hothi P, Cobbs C, Patel AP, Kesari S, Huang S, Baliga NS.

Cancers (Basel). 2021 Jun 24;13(13):3152. doi: 10.3390/cancers13133152.

PMID: 34202449


Familial Psychosis Associated With a Missense Mutation at MACF1 Gene Combined With the Rare Duplications DUP3p26.3 and DUP16q23.3, Affecting the CNTN6 and CDH13 Genes.

Pol-Fuster J, Cañellas F, Ruiz-Guerra L, Medina-Dols A, Bisbal-Carrió B, Asensio V, Ortega-Vila B, Marzese D, Vidal C, Santos C, Lladó J, Olmos G, Heine-Suñer D, Strauch K, Flaquer A, Vives-Bauzà C.

Front Genet. 2021 Apr 7;12:622886. doi: 10.3389/fgene.2021.622886. eCollection 2021.

PMID: 33897758


A Microcosm of Disparities in Breast Cancer: Comparison Between a Private Hospital and a Safety-Net County Hospital Within Los Angeles County.

McClintock NC, Ayabe RI, Salas Parra RD, Kaji AH, Orozco JIJ, Marzese DM, Samuels E, Stern SL, Dauphine C, Ozao-Choy JJ.

Am Surg. 2021 Feb 25:3134821998668. doi: 10.1177/0003134821998668. Online ahead of print.

PMID: 33629873